Te Mātauranga Kura o te Whero mō te Hauora o te Paru: Te Whakanui ake i te Arotake o te Toto

Me Pēhea Te Whanaketia Ai e te Mātauranga Hiko Māwhiti i te Pātiki ToTo ki te Upoko

Photobiomodulation me tōna pā ki te pātiki iti o te upoko

Ko te terāpia o te kura mārō e mahi ana trū ētahi mea i karangatia he photobiomodulation. I runga i te matapae, ka tuku mai i ngā roa koriko motuhake i waenganui i te 630 ki te 850 nanometara e huinga ana ki te kiri ki ō mātou upoko. Ngā roa koriko ka haere ki te mahi whakakīnga i ngā pūkaha iti nei e karangatia ana ko mitochondria kei roto i ō mātou selu kiri. He aha te mea ka rongo ai? Ka whakahohea te protein e mōhiotia ana ko cytochrome c oxidase e taea ai te piki ake i te 200% i te ATP e ai ki ngā rangahau mai i Cellular Metabolism i te 2018. Ko te nui ake o te ATP ko te nui ake o te wairua selu mā te tinana katoa. Koirā te kura e āwhina ai i te pai ake o te rere o te toto mā ngā vēihana iti i tata ki ngā karuwhenua makawe me te tūāpapa o ia taura. Ko te rere pai ake ka kawea atu te nui ake o te hau māori me ngā taputapu ki ēnei wāhi, he mea nui rawa kia mau ai te hauora o tā mātou makawe.

Te whakarereka haumanu mataaho me te whānuitanga o ngā vēihana: ngā tikanga matua i te piki ake o te rere o te toto

Ina hāngai ana te RLT, ka tīmata pea te whakaputa i ētahi hāora o te nitric oxide e ngā sel endothelial, ka whānui ake ngā pūtau toto i te 20 ki te 30 ōrau. Ko te āhua? E neke ake ana te toto i ngā kapihāra iti iti i runga i tō mātou upoko, e 34% ake rānei te tere, e ai ki ngā rangahau i tāngia ki te Journal of Photodermatology i te 2018. Arā, ka tae ake anō te hauora me ngā mea whakapakari pērā i te vascular endothelial growth factor. Anō, ka āwhina hoki ki te horoi i ngā taonga matapo katoa i hua ai i te wā. A, ina tā mātou tā te mea ka iti ake te totohu o te pānga oksikara, ka hāngai pea ki ngā tikanga pai mō ngā karu rākau kia tīmata anō te whakapakari.

Te Angiogenesis me te tautoko roa iho i ngā pūtau toto i te upoko

Ko te whakamahi tūmatanui i te RLT mō te 8 ki te 12 wiki e āwhina ana i te wāhi o ngā kōpiko toto hou trū ake i te wehenga o ngā HIF-1 alpha me ngā pūtau VEGF ki te tinana. I kitea e te rangahau i te tau 2020, i rerekētia ai te huinga kōpiko toto ki te makawe o ngā kaiwhakamahi i te terāpī nei, ka piki ake pea takirua 28% i muri i te 16 wiki o ngā whakatuu. Ko te mea ka rongoa anō hoki he tino hāpai. Ka haere tonu ngā kōpiko iti nei ki te mahi roa, e hoatu ana ngā punaha tukanga ki ia wā o te tipu hairoa, tae atu ki ngā wā e moe ana, e ngaro ana rānei ngā hairoa. Ko te tuku haumanu ake nei e nui ake ai te āki kia ora, kia pakari hoki ngā karu hairoa.

Te Whakangungu i ngā Karu Hairara trū te Whakapakari i te Urutā me te Kaha Wāhiaroha

Me pēhea te urutā pai ake e hoatu ai te hāora me ngā punaha tukanga ki ngā karu hairoa

Ko te whakapai ake i te mīhini e hua ai te tuku kai ki ngā karuwha kaukau, e 69% pea, e tuku ana i ngā amino acid, vitamin, me ngā minerā hei mea nui mō te hanganga keratin. Ko te wātea ohaoha e hoki ārai ana i ngā tikanga hypoxic e kitea ana noa i ngā karuwha iti nei e pa ana te androgenetic alopecia. I te wā kotahi, ko te rere ohaoha e pakari ake nei e horoi ana i ngā hua matapo, e whakaiti ana i te pānga, ā, e āwhina ana i te hoki ake o te karuwha.

Te whakahohe i ngā karuwha moe mā te 650–850 nm o te kiko, ā, te arataki ki te taha o te kiko

Kei te pai ake te mātauranga arataki kōmaru (red light therapy) ina whakamahia ngā roa whatitū e 650 ki te 850 nanometres noa atu, nā te mea ka taea e ēnei te tae atu ki raro ki te mata o te upoko, e 5 ki te 10 mirimita i raro. Ko reira te wāhi e noho ana ngā sel miti motuhake e pā ana ki ngā karu whētiko. Ina huinga te mārama ki te kiri, ka ara ake ngā karu whētiko e moe ana, ka hoki anō ki te takotoranga tipu tika. Kua kite ētahi rangahau i muri i ngā whakaritenga e whā ngahuru, ka kitea e te tangata he toru tekau mā rua ōrau atu ngā karu whētiko e tipu ana i mua. He mea tino mārama nō reira te pēhea i huri ai te nuinga ki te RLT mō ngā raru o te whētiko iti haere. He tino haumaru hoki te tikanga katoa, nā te mea ka taea e te mārama tika te tūhono engari kāore e whara, nō reira ko te huarahi e tohua ana e ngā rongoā hei arataki tipu whētiko kaua ko te kirurgi, kaua ko ngā paraihe kikokiko.

Ngā pānga ki ngā sel: te whakaputa ATP me te whakararangia mitokondria ki ngā sel karu whētiko

Ko te Photobiomodulation ka whakapai ake i te arataki mītihōkīria ki ngā selu karuwha, ka piki ake te hānga ATP 150–200%. Ka āwhina tēnei arataki kaha ki te hurahura wātea o ngā selu i te wā o te anagen, ā, ka heke te mate oksikara. E kōrero ana ngā rangahau mō te pikinga o te 38% i te kotahi o ngā mītihōkīria i ngā karuwha kua tratia, e hāngai ana ki ngā piko kaha ake, piko penei ake, me te whakapai ake i te tere tipu.

Matakitea Tūmatanui mō te Whakamātau Mārahi Kura mō te Nui o ngā Piko me te Tipu

Tātaritanga matarohia o ngā whakamātautau kliniki mō te whakamātau mārahi kura me te whakapai ake i te tatau piko

Kātahi ka mātai ngā rangahau e 12 mai i te tau 2020, i kite ngā kairangahau ko te mātai aroha o te kiko tapawhā i waenganui i te 650 ki te 850 nanometara i hua ai i te 29.3 huvai hou i ia sentimetara tapawhā i te tata ki ngā tāngata kāore i te whiwhi mātai (he tino whakarāpopototia ki te P < 0.001). I te nuinga o ngā tāngata ka tīmata ki te kitea i ngā panonitanga pono i te karaka 12 e ai ki te Rangahau Hautai i whakaatu ai i taua tau. Ina papai ana ngā mōhiotia ki te haora tukutuku e 4 ki te 6 joules i ia sentimetara tapawhā i ia wā, ka kitea e te 8 ki te 10 o ngā kaimātai ngā whakapai ake. E whakaatu ana tēnei mārama ko te tika o te mātai aroha e whakarere ana i te whaihua.

Tauānga tūranga: ngā hua i te 16 wiki ki ngā mōhiotia o te androgenic alopecia

I roto i tētahi rangahau matua nui mā te whakamahi i ngā taputapu kua whakaaetia e te FDA e toru ngā wā i te wiki, i kitea e ngā kairangahau:

• 37% te piki ake i te nui o ngā huvai (Lasers Surg Med 2017)
• 2.1 mm te whakapai ake i te tōke o te huvai
• 89% te whakaiti i ngā wā o te pāpaku haere, i whakapumautia hoki e te whakaahua dermatoscopic te whakaara ara anō o ngā kapa karuwha e moe ana i mua, ā, ina heke rawa atu ki ngā wāhi i te timatanga o te itinga.

Te pūmau ake me te tautoheke ake o ngā putanga o te nekeneke o ngā makawe

I whakaatu ngā raraunga ā muri i te 12 marama, i mau tonu ai te 85% o ngā putanga tuatahi o te nekeneke o ngā makawe mēnā ka whai whakaora noa i ia rua wiki (J Cosmet Dermatol 2021). Heoi anō, i mau tonu ai te 76% o ngā kaimahi ngā whakapai ake e kitea ana (>15% te piki ake o te nekeneke) i te ono marama i muri i te mātai, e tohu nei ko te RLT ka hua he panoni matua roa ki te takotoranga mataora o te upoko i runga ake i te whakarite pāpaku anake.

Te whakahaere i te paradoke: Ko te take biologikā e mārama ana vs. ngā putanga rerekē o ngā rangahau

Kei te tautoheke i ēnei aronga te whakaaturanga taunaha, tae atu ki ngā pūrongo e kōrerorero ana mō te whakakaha o te aronga mītihondriaia e te 142% pērā anō hoki te piki ake o ngā taumata VEGF e te 64%. Heoi anō, he wehe kē ngā hua i te ao whaiaro nā te mea kāore ngā tikanga e whai ana i ngā kēmu i ngā kīnihi katoa. Ko ētahi taputapu e whakamahi ana i ētahi waeera rerekē, arā ko ētahi e mahi ana i te 650 nm, ko ētahi atu ka pai ake te mahi i te 808 nm. Anō hoki, he rerekē ngā rahi o ngā kōpaki o te upoko, e neke ana i te 1.2mm ki te 4.1mm pērā i te pānga ki te nui o te āhua e hāngai ana. Mā te titiro ki ngā rangahau hou, i whakaatu tētahi rangahau nui maha wāhi i te tau 2022 i ētahi mea hihiri i te wā i whakaritea ai ngā tautuhinga mō te mātai. I te nuinga o ngā hua a ngā mātāmata, i heke te wehenga mai i te 53% ki te 18% anake e ai ki te Dermatol Pract Concept 2022. E tohu ana tēnei he nui ake te take o te tinihanga tika mō te tangata kotahi i tā tātou whakapono i mua.

Ngā Tikanga Mātai Mō te Whakapau I te Upoko

Ngā Tautau, Roa, me ngā Tautuhi Mātai mō te Painga Rawa

Kia pai ai te hua o te mātai RLT, e kitea ana e te nuinga o te tangata ko ngā wā 3 ki te 5 i te wiki te mea tika, ka roa pea i ia wa 10 ki te 20 meneti. Ko te raiha o ngā taputapu e whakamahia ana he 650 ki te 850 nm, me te puranga i te tawhiti o 6 ki te 12 inihi i te upoko. Mō te kaha o te putanga, ko te wāhi i waenganui i te 20 ki te 50 mW i ia cm² e hoatu ana i te 3 ki te 6 joules i ia cm² i ia wā, e rite ana tēnei ki te pikinga pai i waenganui i te whai hua me te haumāta. Mō ngā take āhua tūpato, e whakaaro ana ētahi kaiwhakahaere ki te 100 mW i ia cm² engari anake mēnā e arataki ana tika. Ko ngā take roa e pai ake ana ki ngā wā poto i ia rā, 7 ki te 10 meneti anō, tēnā i ngā mātai roa i ia wiki.

Ngā Taputapu Kāinga vs. Ngā Mātai Matua Matua: Te Whai Hua me te Tata

Ko te pānaha LED kaiwhakamahi tata e 100 mW ia cm² te whakaputa, e 34% pakiore ake i te mātātoru mai i ngā puna tohu matua. Nō reira he iti ake te kaha o ngā taputapu kāinga, me nui ake te wā e noho ana te tangata ki raro i ēnei taputapu kia tae pea te rahi o te hiko ki te mata o te upoko. E toru hau eka o ngā tāngata e mau ana ki te kaupapa whakaora kāinga e kite ana i te huringa o te karuwha i te wā. Engari, ina tūhuratia tā rātou ki te tūhonotanga, kei te piki ake te taputapu rongoā i ngā putanga ki te rua tekau pea. Ko te nuinga o ngā kaupapa tirotiro e timata ana ki te haerenga ki te kīni hokihoki, kātahi ka huri ki ngā wā pānui kāinga i muri i te wā tuatahi 12 wiki. Kātahi ka pupuri i te ara kē atu anō i te tautoko a te tohunga.

Ngā Taputapu Kua Whakaaetia e te FDA: He aha ngā āhuatanga e tiaki ana i te haumātauranga me te mahi?

Ko ngā pūnaha RLT e mōhiotia ana e:

• Ngā tiwhikete tukutuku roa (±5 nm te pono)
• Ngā taima tūmatanui (5–30 meneti te roanga)
• Ngā piko takirua māmā (auto-takikore i runga ake i te 104°F)
• Te whai mātai ki ngā tikanga haumaru hiko mō ngā taputapu hauora IEC 60601-1

Ko te whakaaetanga o te FDA e hiahiatia ana te whakamātau tuatoru o ngā kōrero rere-kore-mara ā ngā roanga irahiko bio-stimulative (5–500 mW/cm²). Ko ngā taputapu tua-kīato kei te whakauru i ētahi ararae rua 660/850 nm hei whāinga i ngā karuaka paparua me ngā whatanga vascuar tino-pōroki i te wā kotahi, ka nui ake ai te horoanga terapikihia.

Te whakauru Kiriata Whakaora i roto i tētahi Tikanga Whakahaere Mākūpapa Ūwha Kotahi

Ngā Tikanga Rā ia rā me ia wiki e hono ana i te Kiriata Whakaora ki te Horoi Mākūpapa

Kia pai ai te whiwhi i te painga nui ka taea mai i te mātauranga o te kiko rama mō te upoko, me waiho hei wāhanga o tētahi tikanga noa. I whakaatu tētahi rangahau i tāparangia i te tau ki muri i Dermatologic Therapy i āta tirotiro ana i ētahi atu rangahau, i kitea he mea hihiri. Ko ngā tāngata i whakamahi rama i waenganui i te 650 ki te 850 nanometers 3 ki te 5 wā i te wiki, i te wā i manaaki rātou i te horoi i ō rātou upoko, i kitea pea i te piki ake o te 40% i te uara o te huinga haumiatanga. I mua i te tīmatatanga o tētahi wā, e tino pai ana kia horoia te upoko kia kauaia ngā huaunga me ngā taonga e here ana i tae mai ana te rama, nā te mea ka pakaru pea tana huarahi ki roto. Muri i te mutunga o te wehi, ko te mirimiri i te wāhi e pai ana, ā, ka piki ake te rere o te toto. Nā te mea ka whakahohe te rama i te whanonga o te nitric oxide, e tuwhera ai i ngā arataki toto, ā, ka pai ake te rere o te toto.

Ngā Aronga Tūhonuhonu: Kai, Ngā Wehenga Rerengā, me ngā Hekenga Ao

Whakanuia ngā putanga mā ngā aronga āwhina:

• Tautoko nutrihau : Ko te whāngai rā anuanu biotin (30 mcg) me te zinc (11 mg) e kaha ake ai te hanganga o ngā hūpē ina taraiwa tahi me te RLT (NIH 2022)
• Ngā tohu ā-tinana : Ko ngā pāpā hauora rich in peptide e whakapai ake ana i te koha o te arahu ki te 22% (International Journal of Trichology 2023)
• Te whakapai ake i ngā tikanga noho : Ko ngā mahi whakaaroaro e heke iho ai te cortisol mā te 31%, ā, e āwhina ana i te aukati i te itinga o ngā karu hūpē e te mate korikori (JAMA Dermatology 2023)

Laser vs. Ngā Pūnaha LED: Te Whiriwhiri Mā te Tikanga Kura, Penetration, me te Whai Wā

Ko ngā pūnaha riori matua whai take i ngā wāhi e neke ana i te 5 ki te 7 mita tapawhā, ā, ka tū ake i te 4 ki te 6 mirimita ki roto i te kōpaki. Ka nui ake te mōhio o ēnei āhuatanga mō te whakatika i te wehe wehe mātātoko kei te piko te pono. I te taha aronga atu, ka mahi ngā paparanga LED kāinga ki ngā mata nui ake, e kovera ana i te 15 ki te 20 mita tapawhā, engari me noho roa ake te kaiwhiltri i ia wā, e 15 ki te 20 meneti tonu, kia rite ai ngā hua e hāngai ana ki te whakapau i te ATP. Mō te tiaki haere, e wātea ana ināianei ngā kapu LED e kawe ana e te kaiwhiltri e manawankore ana i te 80% o te mōhio ki te taputapu matua e ai ki ngā tuhinga whakaaetanga FDA 510(k). E mōhio ana maha o te tangata he pai ēnei hei whakamahi tōaitanga, e rua wā i te wiki. He toronga pai mō te katoa e whai mōhio ana ki ēnei taputapu ko te rapu i ngā tauira e whai pūnga herehere huarere ana. Ka āwhina tēnei kia kaua ai ngā raru e hāngai ana ki te hohonu o te wera i te roanga o te wā, ā, kia noho tonu ai ngā wāhanga e urupare ana i ngā wā o te whakatika.

Ngā Pātai Tāpiri

• He aha te huarahi matua e pai ai te maimoatanga mā te mārama kikorangi i te rere o te toto ki te mata? Ko te maimoatanga mā te mārama kikorangi e mahi ana i te wāhi e mōhiotia ana ko te photobiomodulation, e whakarāwekenga ana i ngā mitochondria kei roto i ngā selu mata, e piki ake ai te ATP production me te hauora o te selu me te rere o te toto.
• Pēhea te pānga o te maimoatanga mā te mārama kākāriki ki te whakakaha i ngā karu whakapakari? Mā te whakamahi i ētahi wāhi mārama āhuatanga, ka whakakīia e te maimoatanga mā te mārama kākāriki ngā karu whakapakari e moe ana, ā, ka pai ake te rere o te toto, ā, ka hua ai te hoki ake o te whakapakari i te huri.
• He pai pērā ngā taputapu kāinga ki ngā maimoatanga matua mō te maimoatanga mā te mārama kākāriki? Ahakoa e taea ana e ngā taputapu kāinga te whakaatu i ngā whakapai ake, he pai ake ngā maimoatanga matua nā te nui ake o te kaha o te mārama me te whakapae tika, ā, ka hua ai ngā hua tere ake me te nui ake.
• He aha ngā āhuatanga haumātauranga e rapu mea ana i ngā taputapu maimoatanga mā te mārama kākāriki kua whakaaetia e te FDA? Me whai ngā taputapu kua whakaaetia e te FDA i te tika o ngā wāhi mārama, ngā taima tāpiritia, ngā kowhiringa mō te wera, ā, me whai tikanga ki ngā tīmautanga haumātauranga mō ngā taputapu hauora pērā i te IEC 60601-1.