Ka taea e ngā taputapu PDT te whakaiti i ngā tohu āhua me ngā panonitanga o te mata?

Me pēhea e mahi ai ngā taputapu PDT: Te whai mātua i ngā tohu āhua me ngā panonitanga ki te rūmao wāhanga

Te mātauranga i te Terāpi Arotini (PDT) me tana tuānga ki te whakaora anō i te mata

Ko te maimoatanga hiko-ora, te maimoatanga rānei hiko-ora (PDT) mokowhiti, e mahi ana ma te whakakotahi i te ātaahua me ngā tikanga motuhake e kiia nei ko ngā kaiwhakaora hiko pērā i te 5-aminolevulinic acid (ALA) kia tīmata ai ngā selu ki te whakatika i a rātou anō i ngā wāhi iti. Ko te ALA e torotoro ana ki roto ki ērā rīwhihi hiako hōhā, me te āki ki ngā tohu mate karapoti ka tāpiri tētahi ki te kiri mate. E ai ki ngā rangahau i tākarotia ki te Pukapuka o te Pūtaiao Hauora Koreana i te tau 2023, i te pānga atu o ngā mātātoki e waru ki ngā tekau ka kitea he pai ake te ahunga o te kiri i muri i ngā maimoatanga PDT. Ka taea tēnei nā te mea ina pā te momo ātaahua tika ki te wāhi, ka huri a ALA hei mea e kiia nei ko ngā porphyrins ka haere ka mātāwari i ngā pāpaku e herenga ana ki te karapoti, ā, ko te mea anō ka āwhina i te tinana kia hanga i ētahi atu collagen.

Te Pūtaiao mō te Whakahohe 5-Aminolevulinic Acid (ALA) i roto i te PDT mō te Mate Karapoti

Ina eke ana ki te kiko whero, ka huri a ALA ki te protoporphyrin IX ka whakaputa ai i ngā karuwha oxi (ROS). Ka herekau ēnei ROS i ngā mea e porowhara ana i ngā pōro me ngā sel mu matū. Ko te mea e hāpai ana i tēnei mātai ko te aronga ki ngā wāhi raru, i te wā e mahue ai te kiko hou. E whakaatu ana ngā rangahau mō ALA-PDT, he uaua te 64% iti ake i ngā tohu ārai mate mō ngā tāngata e noho ana ki te ākene hou. Arā, e iti ake ana ngā putanga, ā, he iti ake anō hoki ngā tohu muri i te wā e mahi ana tēnei mātai i ētahi atu take katoa.

Ngā tikanga o te whakahounga o ngā sel me te whakahaere i te melanin trū te PDT

Ko te PDT e whakaora ana i ngā fibroblast me te whakarahinga i ngā matrix metalloproteinases, ka huritao ai te whakarerekenga collagen hei kapi i ngā totohe acne heke. I tētahi tauira JCAD i whakaatu ko te 40% te piki ake i te kotahi kihini collagen i muri i ngā ono wiki. I te wā kotahi, ko te PDT e whakarere ana i te mahi o ngā melanocyte, kaiteka ai te hyperpigmentation muri i te ārai ma te 35% trū te whakaputa tyrosinase—ko te ara huarua nei he iti noa ngā rongoā e tukuna ana.

Ngā taipitopito mai i ngā akoranga mō te Pānga a PDT ki ngā Totohe Acne

Kei te mahi tino pai ngā taputapu PDT mō te whakaritenga i ngā pāpāra mate akime, ā, ina heke noa mai te mate pākanga. I tētahi rangahau i āta tirotiro ai i te hākinakina o te aro kua whakatupua ki te PDT me te microdermabrasion, ka kitea ko te tere o te pāpāra i heke mai ki te 42% i muri i ngā wā toru. Ko te whakaritenga e pai ake ana nā te whāinga e āwhina ana i te tinana ki te whai ake i te ALA me te timata atu i te hua o te collagen. E whakaaro ana ngā mātai ao ko te PDT e rua ngā mahi matua e mahi ana: e āwhina ana i te hoki mai o ngā paraka kiko kua pakaru mā te 'matrix metalloproteinase activity' me te whakamau i ngā tohu mate pākanga pērā i te IL-6. Mō ngā tāngata e noho ana me ngā pāpāra matotoru ake, ko ngā hua hoki he pai tino—e kōrero ana maha o rātou mō te 68% iti ake te māwhera me ngā whakapai ake e kitea ana i te āhua o te mātātoko o te kiko i roto i te toru marama i muri i te timata i te whakaritenga.

PDT vs. Microneedling me Laser Resurfacing: Ka rite pēhea ngā hua?

Ahakoa ko te microneedling e horapa ana ki te mate mekanikihanga, ā, ko ngā lazeri whakaputangia e tangata ana i te puehu, ko te PDT he kōwhiringa māmā ake me ngā tāwarenga iti ake. I tētahi rangahau ōrite 16 wiki:

Ko te pono o te PDT i te whai atu ki ngā rīhi hūparu, me te whakahaere i ngā melanocyte, ka heke te mōrearea o te parurenga hoki e rite ana ki ngā lazeri. E ai ki ngā ripōtere o te American Academy of Dermatology, 78% o ngā kaiwhilwhiltae PDT i te hāunga i ngā hua mō te 12 marama, i te tuarangi ki te 61% mō te microneedling.

Whakapai a-Tōpito ki te Whakaiti a-Roanga o ngā Māmā

Ko ngā rongoā e kitea ana e ngā rata ko te iti ake i te whero me te ahunga māmā ake i roto i ngā wiki 4–6. E takes ana i ngā marama 3–6 kia hou katoa ai te hanga o te collagen, ā, ka heke te rahi o ngā māmā kimihia te 19% ia marama i raro i te mātai tonu. Arā noa me te whakapīria i te mata, e hoatu ana e ia ngā hua tūmatata engari kinokino noa, ko te PDT e āraite ana i te whakahou haere i te huinga pupura—i te tau 2022, i piki ake te 86% o ngā kapa umanga kimihia te ≥50% te whakapai ake i ngā māmā i muri i ngā wā 6.

Te PDT mō te Tae Hautēpu me te Hara o te Kiri i Paia e te Rā

Te Whāinga i te Hautēpu mā te Mātai a Light i Hāngai ai te ALA

Ko te maimoatanga pūhiko-ā-iwi e mahi tahi ana i te 5-aminolevulinic acid (nō te tinihanga ALA) me ētahi roimata kōwhaiwhai e whai mātātoko ana i ngā rōpū melanin e hāpai ana i ngā tohu paru. E ai ki ngā rangahau hou i tukuna ki te Aratohu Huihuinga mō te Maimoatanga Pūhiko-ā-iwi i te tau ki muri, ko te tikanga maimoatanga nei e pā ana ki ngā wāhanga hangarua e hāngai ana ki te āhua o te mata, ā, e āwhina hoki i te hanganga anō i te collagen hei whakapakari i te mata, hei whakamāma i te āhua kotahi. He taonga hoki te aha ka pakaru i te wā o te maimoatanga—ka whakauru te kōwhaiwhai i tētahi arotake kimikimi e māmā ai ngā tohu paru kei reira. Anō hoki, ka āwhina ia i te aukati i te hanganga o ngā āhua hou, nā te heke mai ki te ara tyrosinase e mōhiotia ana e ngā kairangahau, arā anō te ara e hāngai ana ki te hāngai haumanu o te tinana.

Me pēhea te whakāwhiti a PDT i te āhua o te mata, me te whakaora i te mata i maroke ai e te kōwhaiwhai UV

Ko te mātai mate e pā ana ki ngā paraka whakamātauranga kia whakatika i ngā hapa e āhua herekau ana e ngā mātai aho matarua. Mā te whakauru i ngā fibroblasts me te huritanga i te hurihanga o ngā wāhanga, ka pakaru te PDT i ngā tohu parahaki me te hanga anō i te hanganga dermal rich collagen. Ko tēnei mahi takirua e whakapai ai i ngā tohu rā me te whakapakari ake i te manawaroa ki ngā hapa aha ake—he mea matua nui ki te ōrite tonu o te tae.

Te whakahaere i te Whanaketanga Melanin hei Atunu ki te Pānga Parahaki muri i te Mate

Ko te maimoatanga hiko-kīma e mahi tōia ana i ētahi atu maimoatanga, e whakahaere ana i te arataki o ngā melanocyte ina he nui te whakaputanga o te tioata i muri i te pā ki te kiri. Kua kitea e ngā rauemi rangahau ko te PDT e iti rawa ana i ngā tohu mārearea e hoki mai ana i muri i te acne, i ētahi atu whakapīpī hoki ki te kiri, nā te mea ka uru ia ki te tukanga anuanu kei roto i ngā sel e hangaia ana ai te melanin. Ko te mea motuhake o tēnei tikanga ko te aukati i te hanganga o ngā tohu mārearea hou, ā, i te wā e maimoa ana i ngā pānga o waho ki te mata o te kiri. Ko ngā hua e pai ake ana i te whānuitanga i te whakamahi i ngā karāmuri, i ngā ointment rānei e whakapaihia ana ki te mata o te kiri anake.

Ngā Painga Maha: Whakaputa Acne, Whakaiti Mate Mārearea, me te Whakamārama Tino

Ko te maimoatanga hiko-ora (PDT) e whai pānga ana ki ētahi rapunga kiko, e whakahohe ana i te ALA me te whakamahi i ngā roa o wera motuhake. I te tau 2023, i whakaatu tētahi rangahau i te Pukapuka Whai Mātauranga Hautai ko ngā hua he pai rawa. Nō te 78% o ngā kaitākaro i kitea ai he iti ake te rerekenga o ō rātou akene me te hohonu o ngā totohu mā te haurua, i muri i ngā whā maimoatanga. Ko te mea e pai ana ki tēnei tikanga ko te ara e rua e mahi ana ia wā. Ka āwhina te maimoatanga i te kikokiko ki te kapi i ngā totohu atrophic e torotoro ana mā te whakapakari i te whanonga collagen, ā, ka whakahaere hoki i ngā rahi o te melanin. E rua ngā mahi e arataki ana ki te kikokiko e pai ake ai te maroke, me te iti ake ngā totohu pango, ārā anō rānei.

Ngā Tāwhaiwhai Anti-Inflammatory me te Whakahaere i te Sebum Mā te Whakamahi Tūturu i te PDT

Kua whawhai te PDT i te ākene pāmuahia mā te ngaki i ngā pāpaku me te whakahaere i ngā rīhi hinu. I ngā tūhuratanga haumanu, i kitea he iti ake te hua o te sebum 72% i muri i ngā toru whakaritenga, ā, ka roa pea kia ono marama ngā putanga. Mā te whakamāmae i ngā urupare ārai mate, me te whakaiti i ngā karu whānui, ka aukati te PDT i ngā pānga hou, ā, ka iti ake te whero.

Whakaritenga Kāore e Tāwhaiwaia me Te Iti Tangata i ngā Whakaritenga Rongonui

Aratakina atu ki te whakapuaki raser, ki te dermabrasion rānei, ko te PDT anake e hiahiatia ana ngā rā 1–2 noa iho mō te māmārangi pūarataki. Kua whakapumautia e ngā rangahau tana hua ki te whakapakari i te collagen e ū ana ki ngā raser hautaua engari me 83% iti ake ngā take kino. Ko te mea nei ka pai te PDT mō ngā tāngata e rapu ana i te whakarerekenga parurenga e kore e whakararu i te ao whai mōhio.

Me Pēhea e Iti ai ngā Taputapu PDT i ngā Parurenga Ākene me ngā Tae: Te Tukanga Whakaritenga Ka Whakamārama

Me Arotake: Te Tukanga Whakaritenga PDT me te Wheako Tāngata

Te Aratohu Ngātahi ki ngā Wā Oraite, ki ngā Wā Whakaritenga PDT Ki Te Kāinga Rānei

Ko te tikanga terāpi hiko-ora tōmuri e timata ana. Tuatahi, ka pakaru mātātoko i te kiri ki te acetone kia mātātoko ngā hinu katoa, ka whakaputangia kia ALA. Ko te hōhipera e whakaae ana kia noho tonu ki te kiri mō te haora me te haurua, ahakoa he iti ake te wā mō ngā putanga kāinga nā te kore e hiahia rawa atu te tangata ki te tatari. I muri i taua wā inumia, ka whakaputaina ngā hiko kākāriki, kākārangi rānei ki te wāhi e tiimata ai te mahi a ALA ki roto i ngā sel kiri kino. E pīrangi ana ētahi ki te mōhio ki te rerehua iti nei i raro i ngā hiko, engari ko te nuinga e kitea ana e āwhina ana ngā taputapu whakamaroke i te noho pai. E ai ki ngā rangahau i tukuna ki te Pukapuka Whakaritenga Kiri i te tau ki muri, i te 70% te heke i ngā tae muri i te whakaputa māori i waenganui i ngā tāngata i toru ngā wā i whai i tēnei whakaritenga. Ehara i te mea kino mō ētahi mea e rongo ana pērā i te pūtaiao-pūtaiao ina koreroa i runga i te reka kawhe.

Te Tatawehe Whakaritenga me te Rārangi Wā Hoki

Ko te nuinga o ngā tāngata e hiahiatia ana mō te toru ki te rima wā o ngā hui mātai, e whakaritea ana i ia rua wiki pea mō ngā putanga pai. Ka pau pea i te iti ake i ngā rua haora katoa ngā wā pānga mai ki te wehe atu, ka whai mātai i te tīmatanga ki te mātai anuanu. I muri i te mahi nei, ka ripoata te waru ki te iwa o ngā tāngata mō te whero me te parurenga o te kiri e toru ki te whitu rā pea. He āhuatanga noa tēnei nā te tohu kia whakakīia e ngā sel kiri hou ngā tuawhenua. Ka kitea e te nuinga o ngā tāngata he omaoma tonu i muri i te tekau rā. Mātua motuhake a PDT i te upoko o ngā mātai laser takirua e hiahiatia ana mō te wā roa ake hei whakaora, e whitu ki te tekau mā whā rā pea. Nō reira ka mārama kia pirangi ai te nuinga ki te aronga mātai. E ai ki ngā rangahau hou i tukuna ai i te tau ki muri e pā ana ki te 450 ngā here, i te 88 ōrau i oti katoa ngā wā mātai PDT nā te mea i āhua māmā ai ngā ahuatanga taha. Mō te tiaki i te kāinga, e wātea ana ētahi taputapu i te mātāpona ināianei. Ahakoa ko ngā dermatologist e whakaatu ana kia hui haere ngā tāngata e herenga ana ki ngā parurenga uaua pea, kia kotahi pea i ia toru marama mō ngā whakatikatika matua mena e hiahiatia ana.

Ngā Hua i te Ao Tūmatanui: Ngā Painga mō te Kiri me ngā Hokihoki

E ai ki tētahi rangahau i whakaatuia ki Clinical and Aesthetic Dermatology i te tau 2022, i te penei o te toru hauwhā o ngā tāngata i whakamātau i te PDT i kitea e kore ana ngā totohu mate kiri e rite ana i muri i te painga i ngā wāhanga whakapai e whā. I ētahi atu hoki, kua pai ake te āhua o te kiri, me te whakapai ake i te 33% i te āhua whānui. Ki te titiro ki te pikinga o te whakapono ki te ake, i whakaatu tētahi anō uiuinga mai i te Skin Health Institute i te 2021 ko te penei o te whitu ki te tekau o ngā mōrehu i āhua pai ake te whakaaro ki a rātou anō nā te mea kāore he aha te rerekētanga o te kiri. Mō ngā tāngata e noho ana me te mate kiri horomona, i whai hua hoki rātou. I kitea e te tangata he iti ake te 60% ngā tupeka, ā, ka māma haere ngā totohu tawhito i te huarangi o te ono marama. Ko ēnei katoa ngā kitenga e tohu nei ko te PDT he nui ake i tētahi whakatika marie—ka whai kiko ki ngā āhuatanga maha o ngā raru kiri e hua mai ana i te mate kiri.

FAQ

He aha te Whakapai Rongoā Māmā (PDT)?

Ko te Maimoaikura (PDT) he whakaritenga e whakamahia ana ai te mārama me tētahi huinga haututū ki te whāinga, ki te whakaritenga i ētahi aronga mata pērā i ngā totohu ākene, i te tōkiri rānei.

Me pēhea te mahi a PDT mō te ākene, mō te tōkiri hoki?

Ko te PDT e whakaora ana i tētahi huinga ko 5-aminolevulinic acid (ALA) mā te mārama. Ka pakanga tēnei tikanga ki ngā pāpaku e āwhina ana i te ākene, ā, ka whakapau kia hua te collagen hei whakaiti i ngā totohu, i te tōkiri hoki.

He whai hua anō te PDT mō ngā totohu ākene matatau?

He whai hua te PDT ki te whakaritenga i ngā momo totohu ākene. Ka whakapau kia hua te collagen, ka whakaiti hoki i te pānga pārehe, e tino pai ai ngā totohu matatau i te wā.

E hia ngā wā whakauru PDT e hiahiatia ana kia kitea ngā putanga?

He tata ki te 3 ki te 5 ngā wā whakauru, e wehe ana i ētahi wiki, ka tūtohua mō ngā whakapai ake i ngā totohu ākene, i te tōkiri hoki.

He aha te mea e hiahia ana ahau ki te tiro i te wā o te wā whakauru PDT?

I te wa o te wā session PDT, ka parakore kōpae, ka whakaputangia te ALA, ā, muri i te wā whakauru, ka whakamahia te mārama hei whakahohe i te mātai. Ka taea e koe te kitea he aha te ahunga.