Me pēhea e whakatakarotia ai te Whakaputa Kura mā te Whakaputa Kura

Te Whakamārama i te Photobiomodulation me Tōna Rōl i te Whakaora Mātai

He aha te maimoatanga photobiomodulation (PBM)?

Ko te maimoatanga PBM e mahi ana ma te whakaputa i ētahi tae ārai, ina koa te kākāriki me te peneiti karahipi (kei te 630 ki te 850 nanometara) ki ngā rongoā kia tīmata ai te whakaora ki te taupapa selula, kaore he wera e hua mai ana. Ko te tikanga e here ana ki ngā panoni kimikale engari kāore ki ngā pānga wera. Heoi anō, ko te maimoatanga e huri ana ki te mea e kiia nei ko cytochrome c oxidase e noho ana ki roto i ō mātou mitochondria, ko ia hoki te mea matua e āwhina ana i ngā selu ki te hāngai i te hiko. Kua whakaatu hoki ngā rangahau i ētahi hua tino pai. E ai ki ngā rangahau hou i tākarotia i te tau 2023 e Felician me ana hoa, ko ngā selu i te ao o te maimoatanga PBM e hāngai ai i te ATP e 150% ki te 200% atu i ngā selu kāore i maimoa. Ko te pekena nui ake i te wātea hiko e āwhina ana i ngā rongoā kua pakaru kia hanga anō tahi atu tere ake i te wā e hiahiatia ana.

Ngā Tikanga o te Maimoatanga Tae Kākāriki i te Whakatika Selu me te Hāngai Anō

Ko te mātauranga arataki kura e huroroa ana i te whaiwhai mā roto i ngā tikanga matua e toru:

1. Te whakahohe i te mitochondria : Whakanui ake i te uara o te hokohoko irahiko, hei whakapakari i te huarahi ATP mō ngā mahi whakaora
2. Te whakahaere i ngā wāhanga hauropi (ROS) : Tiakina te taurite hauropi pai, me ngā rangahau e whakaatu ana i te 6% atu o te hekenga o ngā ROS ki ngā whaiwhai pūpāhua
3. Te whakarua i ngā hua whakapakari : E 32% ake te TGF-β1 ki ngā whatukuhā kua tapahia (Hendler et al., 2021)

Ka hamaia ēnei panonitanga ki ngā painga haumanu e taea ana te ine—e korerotia ana e ngā tauāroro hautoru he 40% ake te tere o te kati whaiwhai i ngā whaiwhai mate harakeke ina tāpirihia te PBM ki te tiaki whakamutunga.

Mai i te selu ki te whatukuhā: Me pēhea te whakapai aha a te mātauranga arataki kura i te whaiwhai

Ki te taumata whatukuhā, ko te mātauranga arataki kura e taraiwa ana i ngā mahi whakaora matua:

Te whakauru i te ara tohu PI3Kβ/STAT3 e whakahaere ana i ēnei urupare. I tētahi tātari meta 2023 ka kitea ko te whakamahi i te ao 660 nm ki te 4 J/cm² i pēra ai te penenga wā mō te 19.7 rā i ngā whatiwa herenga hoki mō ngā rīpoata 1,452.

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Te whakarāwekenga Mitochondrial me te whānui ake i te ATP Production i ngā selu kua pakaru

Ko te maimoatanga mā te ata whero e pā ana ki ngā mitochondria, ka whakahohe i te cytochrome c oxidase i roto i te haora 630–850 nm. Ka pai ake te hua o te ATP e 70% rānei i ngā sel e mate ana (Ponemon, 2023), e tuku ana i te kaha e hiahiatia ana mō te whakaora. Ko te aronga anō ko te heke i ngā tohu mate kirihau e 41%, ka whāngai ai i te taiao pai mō te ora.

Te Whakahohe i te Hua o te Collagen me te Mahi a te Fibroblast

Mā te whakapakari ake i ngā hēkina TGF-β, ka piki ake te hua o te collagen type III—he mea matua nui mō te hanganga tuatahi o te paru. E whakaatu ana ngā raraunga ārahi ko ngā fibroblast e neke ana 2.3 ngā wā tere ake i ngā paru i maimoatia, ā, e kitea ana te pikinga o te kotahi o te collagen i roto i ngā 72 haora i muri i te maimoatanga.

Te Pikinga me te Neke a te Keratinocyte i raro i te Ata Whero

Ko te roa o te uarangi 660 nm e āwhina ana i te epithelialization mā:

• 38% tere ake te mitosis o te keratinocyte
• Te pikinga o te whakawhitinga integrin mō te pānga sel pai ake
• Te whakarerekenga i te MMP-9 mō te whakarākei i te matrix extracellular

Tautokotia tēnei whakangāhau pakari i te hoki anō ki te reepuhi anō anō, kāore he totohu māmā.

Te Whakahohe i te Tiriti PI3Kβ/STAT3 mā te Mātauranga Rua Kiriata

Ko te mātauranga rua kiriata e whakahohe ana i ētahi ara kotahi e rua:

1. PI3Kβ ka whakapai ake i te tango karawhiti (2.1x te take), arataki i ngā herekore hou mō te healina
2. STAT3 ka whakapakari ake i ngā taraiwa anti-apoptotic pērā i te Bcl-2

Ko tēnei mahi takitahi e 57% te peni i ngā tohu apoptotic, i te wā e whakapai ake ana i te whakapuaki o te vascular endothelial growth factor (VEGF), ka pai ake ai te tuku toto ki ngā whatukuhā kua huaina.

Te Moriori i te Pāpāhua me te Tahumaero e Tautoko ai i te Hohou

Ngā āhuatanga anti-pāpāhua o te mātauranga rua kiriata i ngā paru marino me ngā paru roa

Ko te mātai rā whero e whakarerehua ana i te pānga kirihou mā te whakapau i ngā cytokine pānga kirihou pērā i te TNF-α me te IL-6, i te wā e aukati ana hoki i te piki haere o te IL-10 anti-kirihou. Ko tēnei panonitanga, e hāngai ana ki te whakakaha i te ara NF-κB, ka heke iho te pānga ā-whānui me te urutanga o ngā neutrophil i roto i ngā rā 10–14. Hei whakamātautau hauora, he nui te take o tēnei hua mō ngā whatiwa kua tapahia me ngā aronga roa pērā i ngā whatiwa parurenga kaki.

Te whakarerehua i te cytochrome c oxidase hei whakaiti i te stress oksidatiki

Ko te mātauranga arataki kura whero e hāungia ai te mahi a cytochrome c oxidase i r somewhere rānei i te 18 ki te 23 ōrau e ai ki ngā rangahau mai i te Journal of Biophotonics i te 2023. He aha tēnei e whai wāhi ana ki ā mātou sel? Nō reira, ka māmā ake ngā mitochondria ki te hāngai ATP kei te wā kotahi ka iti ake i te 32% ngā momo hauhake kino e mōhiotia ana e te sel i raro i te parirua. Kei te etahi mea hoki e āhua hou ana i konei ko hormesis kei hea he pikinga poto i ngā taumata ROS e kī ana pea i ngā pūaitanga anti-oxidant a tō tātou tinana pērā i te superoxide dismutase me te glutathione peroxidase e timata ana ki te mahi. Mō ngā tāngata e noho ana ki ngā poka rāwekenga, ko te whakakotahi i te mātauranga arataki kura whero me te tiaki hauora noa e hua ana i te tango i ngā tohu paruparu oksikaraite i te wā e 40% tere ake i te kore. E mārama ana te take ka tīmata ngā rongoā ki te mōhio ki tēnei ara.

Mātauranga Hauora me ngā Whakamātau-a-Tinana o te Mātauranga Arataki Kura Whero

Ngā tūhuratanga hōpūkai e whakaatu ana i te pikinga o te whakaora rata ki te mātauranga kiko waiata

I tētahi rangahau i tāwhiria ai i te tau 2023 ki te puka Wound Repair and Regeneration i titirohia ai ngā 37 rangahau rerekē e pā ana ki ngā 2,148 pānui. I whakaatu ngā hua ko ngā tāngata i whiwhi mātauranga kiko waiata i ora noa i te 38% tere ake i ērā i arataki ai i ngā tikanga whakarāpopototanga noa. Ki raro i te karuwha, i kitea hoki ētahi mea hou ngā kairangahau: i piki ake te mahi o ngā fibroblast mai i te 27%, ā, i piki ake anō hoki te collagen i te kiko waiata i te 19%. Kāore i te noho i tētahi momo raru anake ēnei pikinga. I kitea e ngā rongoā ngā hua pai e hāngai ana ki ngā raru o muri i te whaiora, ngā raru mai i te moe roa, i ngā raru hoki mai i ngā taupatapata me ngā ririhau.

Ngā pānga o te Photobiomodulation ki te whakaora rata i ngā ririhau mate ngerengere me ngā ririhau ahi

Mātai ana i ngā waru o te wāwāhi mate harakeke, i tētahi rangahau hou i te tau 2023 ki te 94 kaimahi, i kitea ko te 62% pea nōna rānei ngā wherenga i hou katoa i roto i ngā ono wiki anake ina whakarerekia te maimoatanga mā te terapī aitua 850 nm. He mea whakamārama tēnā mōhio e mātātoko ana ki te 34% anake te tere hou i te rōpū whakahaere. I te mea anō i āwhina ai i ngā pātiere mate mōmona i tēnei ara maimoatanga. Ina hoatu ngā wātapu o ia rā o te aitua 630 nm, ka rongo rātou i te 41% pea te heke i ērā wherenga mōmona makariri. Ko te take e mōhiotia ana he mea e pā ana ki te aronga o te aitua ki tētahi mea i te tinana e kiia nei ko ngā ara tohatoha TGF-beta 1. E katoa ana ēnei hua e tohu ana ki te āhua o te pōtatai arataki e mōhiotia ana hei whakapono kia pai ake te tarukino me te pānga mōrearea e pā ana ki te maha o ngā rōpū pātiere matatau e herenga ana ki te hounga wherenga tika.

Ngā Parāmetara Maimoatanga Pai Mo Te Terapī Aitua Whero

Ngā Parāmetara Matua Mō Te Dosing: Uara Uara, Iratihana, me te Pānga

E hiahiatia ana te terapī aitua whero kia tāroa te dosing i roto i te 610–690 nm te roanga mō te whakauru me te haumārata. E toru ngā aronga matua:

1. Taurangi Wāhanga : 630–670 nm ka nui ake te whakahohe i te cytochrome c oxidase kāore he pānga mahana
2. Tauwhiri : 55–87 mW/cm² ka tuku mana e āhua ai mō te hanga ATP kāore he pā ki ngā selu
3. Te Rua o Te Ra : 10–15 J/cm² ia wātaka ka whakahohe pai rawa ai te rongoā i ngā whatiwa mate pūpahi

No te ahunga atu o te kurva urupare ki te rāwekenga, ka taea pea te pānga oksida iti pea mena e neke ake ana i te 300 mW/cm², ā, ko te itinga koretake ka herea te pānga rongoā.

Te Taurite i te Pānga Whai Hua me te Haumārata i te Māwhitiā o te Kura

Ko ngā tikanga motuhake he wā poto (5–15 meneti) kia kaua ai te whakapae i te ra. Ko ngā kairongoā e tīmata ana ki te toru ngā wā ki te wiki mō ngā whatiwa e kore e rongoā, ka huri ki ngā rongoā ia rā kia hōhonu ake te rongoā. Ko ngā tohu haumārata ko:

• Mātāwai tiaki mā ngā roanga uarā i raro i te 850 nm
• Te pupuri i tētahi tawhiti o te nuinga o te 12 inihi mai i te kiri
• Te whakatāwhai i te maimoatanga ki te pā ki te māmā o te wera

Whakaatu ngā tātari-ā-huinga mōhio kaore he pāga e puta ana ki te DNA ina heke iho te nohi ki raro i te 200 mW/cm², ka whakapumautia ai te PBM hei tautoko haumaru, iti te mōrearea ki te maimoatanga arataki mō ngā paru.

Ngā Pātai e Patai Pūnoa Ana

He aha ngā tikanga e mātua maimoatia ana e te maimoatanga photobiomodulation?

Ko te photobiomodulation anō e āwhina ana i te houinga paru, engari kei te whai hua hoki ia ki te maimoatanga i ngā tikanga kiko, pērā i te acne me te psoriasis, te whakaiti i te pāpāhua, me te whakapakari i te tupu makawe.

E iai ana ngā pānga tāpiri o te maimoatanga mārama whero?

Ina whakamahia tika, ko te maimoatanga māmā whero e whakaaetia ana he haumaru, he iti noa ngā pāga. Ko ngā pāga rare e taea ana ko te whero, te pāpaku rānei ki te wāhi i maimoatia.

E hia te roa o tētahi wā maimoatanga māmā whero?

Mehemea te roa o te maimoatanga i waenganui i te 5 ki te 15 meneti ia wā, e hāngai ana ki te tikanga e maimoatia ana me te tikanga motuhake e whakamahia ana.

He tino pai te maimoatanga photobiomodulation mō ngā momo kiko katoa?

Āe, ko te photobiomodulation he kore-kī, ā, he tino pai mō ngā momo kiko katoa me ngā tae.