Ngā Tāpoi PDT mō ngā Kiri Māmā: Hei Whakaiti i te Whakapīpī

Me pēhea e mahi ana ngā Tāpoi PDT me ō rātou pānga ki ngā Kiri Māmā

He aha te Tāpoi PDT me pēhea e whai whakaarahia ana i ngā Aranga Kiri?

Ko ngā taputapu terapia hiko-tuira (PDT) e hono ana i ngā hua whakauru hiko me ngā roa-ūaho hiko whaiā teka kia maimoa ngā aranga kiri. Ko te tikanga e toru ngā wā:

1. Ko te kaiwhakauru hiko (he nuinga o te karāmuri, he kirimea rānei) ka whakaputa ki te kiri.
2. I te wā te wā whakaputanga 30 meneti ki te 3 haora , ka hui te mōhiotia ki ngā sel abnormal.
3. Ko tētahi roa wāhi ā-tio irirangi e whakauru ana i te takotoranga, e hāngai ana i ngā moutere oksijeni (ROS) e ngaro ai ngā sel kua pakaru engari kāore ngā papa atamira.

Kei te whakamārama tēnei aronga i te pono o PDT mō te whakaora i te actinic keratosis me te acne, he iti noa te raru o te parurenga i te whanonga whakauru.

Te Tūwāhinga o te Māmā ki te Tio i ngā Hua Whakaora a PDT

Ko te āhua whai hua me ngā whakapākanga e puta ana i te mātai arahu, he nui te painga ki ē rua āhuatanga: ko te roa o te uarangi o te arahu e whakamahia ana, me te roa o te wā e noho ana tētahi ki reira. Mō ngā kiri māmā, ko ngā wā poto ake, pea 30 ki te 60 meneti, ka mōhiotia kia iti ake ngā urupare māmā. I tētahi rangahau hou i te tau ki muri i tēnei, i āta āta tirotiroa tēnei kaupapa mā ngā whakamātau matawekenga, i whakawhitinga anō i ngā tikanga PDT tūmatanui ki ērā i mahia ai i te wā pōuri. Mō ngā kiri tino whakapāpaku, ko te hiahia o ngā tohunga kiri he whakamahi i te arahu kōkōrangi māmā, pea 415 nanometra, engari kāore i te arahu kākāriki kaha 630 nm. E kore pea tēnei ara e whakangāwari ana i te whakapāpaku, engari e mōhiotia ana kia iti ake te pāpaku, he mea nui tēnei mō ngā rata e heria ana ki te māmā muri i ngā mātai.

Ngā Tikanga O Ngā Panonitanga Whakakaha Me Te Arataki O Te PDT

Ko te hua o te PDT e hua mai nei he takirua urupare matua:

• Whakakaha : Whakangāwari i ngā cytokine whakapāpaku penei i IL-6 me TNF-α.
• Arataki : Ka whakaeke ake i te hanganga glutathione umataroa 40% ki ngā fibroblast (JKMS 2024).

Ko ēnei mahi e rua e pai ana te PDT mō te whakahaere i ngā pikinga rosacea me te eczema.

He aha ai te wehe atu o te kiri māmā ki te terāpi kaupapa tiawhati

Ka taea e te arataga kua pakaru o te kiri māmā te hura haere tere ake o te kaipāpaku tia, ka whakanui ake i te exposure ROS ki ngā mutu kōrero me ngā sel kōhure. I whakaatu ngā rangahau i te werainga histamine 68% ake i te kiri māmā i te wa o te PDT tēnā i te kiri noa.

• Whakamahi i te aminolevulinic acid 6% engari kāore i ngā kōnehu 20%
• Whakanuinga i ngā wā tapai muri i te maimoatanga umanga 48–72 hāora

[^1^]: Arataki ki ngā taipitopito o te tikanga PDT mai i tētahi rīpoata matū hauropi mana.
[^2^]: Tuhia ngā raraunga ā-tuuru matatū mō ngā urupare histamine ki te kiri māmā.

Ngā Pānga Matawetawe Matua o ngā Taputapu PDT ki te Kiri Māmā

Ahakoa kei te whai hua ngā taputapu PDT mō te acne me te mārearea o te mārama, e urupare ana te mātātoko mātātoko i te wā o te whakarongo. Ko te mārama ki ēnei urupare he mea matua hei whakaiti i te mamae me te whakanui i ngā putanga.

Te āta kite i ngā urupare o te kiri i te wā me muri i te PDT

Ko te toru haurua o ngā tāngata e pa ana ki te PDT e urupare ana me te whero me te pāpāhua tūmatawhāiti i muri i te timatanga o te whakarongo, aronga tonu i roto i ngā meneti 15, kāore i te roanga ake i te ako 2023. Ko te take? Ina pā te mārama ki ngā kimikimeka photosensitizer ki runga i te kiri, ka hua mai he urupare pāpāhua e whakaputangia ai ngā vēihikila toto i ngā whatumanawa. He nui ngā tāngata e kī ana i te ahuatea i tēnei wā – i ētahi wā ko te mahana anake, i ētahi atu wā ko te rereketanga kiko. Ka piki ake ngā mamae nei ina whakamahia ngā māramarama kikorangi, kōwhai rānei.

Whakahaere Kore Māmā me te Whero i te Wā o ngā Wā Tahumaero

Kaitekau kaitekau te āhuarangi kia 30–50% te iti ake mā ngā tautuhinga o te kikoiti me te arotake i te wera o te kiko i te wā e rerekē ana. Ka āwhina ngā taputapu hōuke, ngā paraihe pia taru taru, me ngā wā tahumaero poto ake i te noho tika ake mō te kiko maroi. Ko ngā kainoho ki te rosacea, ki te eczema hiahiatia e 25% te iti ake i te kikoiti arataki i ngā tikanga matua.

Te Roa me te Rangimārie o te Mata Kua Pīrau i muri i te Whakamātautau PDT

Ahakoa ka kitea e te 84% o ngā kaiwhilwhi i te whakapari atu o te mata whero ki roto i ngā haora 72, ko ngā kaiwhilwhi mata maro ka pā tonu te rekaengaa i te 18% o ngā take. Ka taea e te mata i pakaru ai te arataga te whanaketanga o te maroke, ā, 5–7 rā pea te roa, e hiahiatia ana ngā hinu kore-pūpahi ki te panthenol me ngā piaiti o te taro kia huritau te hoki mai.

Ngā Aronga Tōmuri hei Heke i te Māmāki mai i ngā Taputapu Whakamātautau PDT

Te Tiro Whakamātau i te Maro o te Mata I Mua i te Tīmatatanga o te Whakamātautau PDT

He mea nui te tiro atamira ki te kiko o tētahi tangata i mua i te whakamahi i ngā taputapu PDT kia ārai i ngā raru e tū ake ana i muri ake nei. E whakaatu ana ngā rangahau ko te 62 miriona pea o ngā urupare kino ka tū ana heoi anō i te hīanga e ngā rongoā te titiro ki te āhua paku paku o te kiko, ā, i te pukapuka rangahau Journal of Cosmetic Dermatology i te tau e pā ana. E hia ngā ara hei whakatau i tēnei āhua. Ka āwhina te wāhanga Fitzpatrick ki te whakatau i te momo kiko e ahu mai ana i tētahi, ā, ko te ine i TEWL e hoatu ana i ngā tau e pā ana ki te pono o te arataga o te kiko. Ko ngā tāngata kāore o rātou kiko i ngā lipid e hiahiatia ana ka hiahiatia pea he mātai hou hou i mua i te noho i raro i ngā mārama. Ka taea e tēnei waehenga hou te whakarerekē i te mātai angitu i te mātai kua pauna ai ngā putanga kore e hiahia ana.

Te whakarerekē i ngā Tautuhinga Taputapu PDT mō ngā Momo Kiko Māmā

Ka taea e ngā utauta e rerekē ana te haumanu mō ngā kanohi e pā ana:

I ngā tūhuratanga haepapa, i te whakaperetia i ngā kōpae pōtae-ara rahi ake (he iti ake i te 10% aminolevulinic acid) me ēnei panonitanga, ka heke te tere o te huruhuru mā koi ki te 73%.

Te Taunahatanga o te Tūhura Pirepire ki te Whakarere i ngā Arotake Mōrearea

Ko te Pūrongo Hauora Hautai a 2024 e tohu ana ko te whakahaere i te tūhura pirepire i te waewae māwhai 48 haora i mua i te mātai katoa e tīmata ana i te 89% o ngā keehu e tino mōrearea ana. Ko tēnei mahi maama anake e whakaatu ana i te pānga o te ira tangata ki ngā huinga hautai pōtae-ara, e taea ai e ngā kaiārahi kia:

• Whanui ngā wā inu
• Huri ki ngā rongoā PS kua pakia ki roto i ngā nanoparticle
• Tohua mō te whakamātau i ngā rongoā anti-inflammatory ina hiahiatia

I te nuinga o ngā rata (92%) i whiwhi fewer āhuatanga matarua pērā i te erythema mōrearea i ngā tūmomo kiri, i te wa i whiwhi rātou i ngā whaiāipo tātari.

Ngā Tikanga Pai Mō Te Tiaki Kiri Māmā I Muri I Te PDT

Ngā Huarahi Matua Mō Te Hoki Tūturu I Muri I Te PDT

I muri i te mātauranga PDT, e hiahiatia ana te tiaki tino arataki mō te kiri māmā kia iti ake ai ngā whakapākanga me te whakatairanga i te hoki. I kite tētahi rangahau 2024 e UCSF Health, i wāwāhi 83% o ngā rata i ngā take kino mā te arataki i ngā tikanga toru matua:

1. Kaua e noho ki te ao mārama tika i ngā haora 48–72 i muri i te mātauranga
2. Whakamahia te wai paraire me ngā horoi kore-mārore
3. Whakaputangia ngā kōpae whakamarumaru pērā i te petroleum jelly hei pupuri i ngā here takotoranga

E mōhiotia ana e te pūkenga hauora, ko te whero e piki ake ana ia 24 haora engari ka neke atu i ngā haora 72 i 90% o ngā keehi ina arataki ana ēnei tikanga.

Tiaki i te Kiri mai i te Ao Mārama me te Whakakorenga UV: Ngā Tautoheira Hauora i Muri I Te PDT

Ko te kiri māmā e noho ana hei whakapūmau ki te ataata i ngā wiki e 4 i muri i te PDT nā ngā pūtini e hāngai ana ki te rama. Ahakoa he mea matua herekau te sunscreen SPF 50+ ā-rohe i muri i te wā tuarua o ngā haora 48, ngā aukati tinana pērā i ngā kapu whanui-ripa me ngā kakahu UPF 50+ e tuku ana i te tiaki pai ake i ngā wā tapaunga tuatahi.

Whakamāmā i te kiri e mate ana ki ngā tikanga māmā, kāore e whakapīrangi

Ka pā taua rawa te māuiui i muri i te PDT ki ngā raihana eauwā ana i:

• Te hononga Hyaluronic (0.2% te rahi) hei whakakī i te wai kaua ko ngā pōru e tapaia ana
• Ngā Ceramides (pūhuihiranga otinga toru) hei whakatika i te mātai arotake
• Kōnini oatmeal (1–3% kōpae) hei whakaiti i te whakaaweawe

I whakaatu tētahi tauanga o te Pukapuka Jornal of Cosmetic Dermatology 2023, i āwhina ai te whakakotahi i ēnei matū ki te penapena wā 40% i te wā whakahou i ngā kōminga arataki. Me whakakore ngā huinga poukai pērā i ngā rino, ngā hinu taumaha rānei i te wā tuatahi 72 haora inā heke tonu ngā poro.

Ngā vantepara o ngā Tāpoi PDT mō te Whakahaere Roa i te Kiri Māmā

Te Whakaritenga Kāore e Tīmata ki te Mate Māmā

Ko ngā taputapu PDT e whai ana i tētahi huarahi kāore he totohu mō te whakahaere i ētahi take mātāmuri e pā ana ki te kiko, kāore hoki e hiahiatia he tarau, he wā roa rānei mō te hoki tonu i muri i te whakarongo. E whakaatu ana ngā rangahau ko ēnei taputapu e mahi ana i tō rātou aroha mā te whakamahi i te ao ki te whāinga anake i ngā wāhi kino, ka waiho ai i te kiko pai kei ngā tātā e takoto ana. Nō reira nui ake te aronga o tēnei tikanga, he iti ake te tūponotanga o te hinga i ngā totohu māmā, tērā i ngā tikanga matapihi tawhito. He rīpoata ētahi ko te tūponotanga o te hinga i te totohu e heke ana pea ki te 80 ōrau, ahakoa ka rerekē ngā tau e hāngai ana ki ngā take takitahi. Ko te mea nei ka pai ake a PDT mō ngā tāngata e māmā ana, e māwhera ana hoki te kiko i muri i ngā tikanga.

Te Whakareretanga a PDT ki Ētahi Atu Rongoā Kiko mō te Kiko Mātāmuri

Ko ngā retinoid tōpiki me ngā maimoatanga rātori e māmā ana i te kiri pīroiroi i ētahi wā, engari ko te maimoatanga arotinihinihini e mahi ana i tētahi ara kore ai te māmā. I whakaatu ngā rangahau i te aha o te PDT i te whakapae i ngā wāhi raru, kaheke ai ngā raruraru pērā i ngā tapawhā kiri kua pakaru i te rā, i ngā tu ake hoki, kāore i te whakangāwari i te kiri houngia. Tēnei tētahi rangahau hōhonu: i whakāhua ngā kairangahau i ngā tāngata i maimoa ki te PDT ki ētahi atu i whiwhi kīmuera anti-pāpātū. Ko te rōpū PDT i te nuinga o ngā urupare kino, heoi anō i kitea ngā hua ōrite i muri i ngā marama whai muri. Ko te pono o tēnei maimoatanga, tahi atu ko te itinga o te raru, ka pai ake mō ngā nuinga o ngā nuinga e rapu ana i ngā tikanga takitahi.

Te Manaaki Roa me te Harikoa a te Tāngata ki ngā Taputapu PDT

Whakaatu ana ngā tūhuratanga ko te 89 ki te 100 o ngā tāngata e pāngia ana te mātāpuna mata, ka hoki pai ake muri i te whai i te maimoatanga PDT mō ona rautau e ono. He nui hoki te hari, me te 92 ōrau e whakapuaki ana kua hoki pai ake te āhua me te aronga o te mātāpuna mata, āhuareka tonu ki te whero. Ko te mea e tīmata ai te PDT i ngā atamira atu koia he mea kāore e hiahiatia ngā rongoā tūhono. Ka tipu haere ngā mea pai me te wā, nō reira kāore e hiahiatia rawa ngā karāmi korotēroi, i te karaipihikete rānei. Ā, e ai ki ngā uiuinga hou, kei te whiriwhiri pea te toru hauwhā o ngā mātāwaka mō te PDT ina tukuna mai he kōwhiringa mō ngā maimoatanga rerekē, nā te mea e mihi ana ratou kia kaua e tangohia te wā i te mahi, i te wā hoki ki te ora anō roa. Anō hoki, kei te roa ake ngā putanga anti-inflammatory i te nuinga o ngā maimoatanga takitahi.

FAQ

Ka taea e ngā taputapu PDT te maimoata i ēhea momo mate mātāpuna mata?

Ka taea e ngā taputapu PDT te maimoata i ngā mate pērā i te actinic keratosis, te acne, te rosacea, me te eczema.

Pēhea te pā ki te mātai PDT te kiri māmā?

Ko te kiri māmā e hūtia ana ngā kaiwhakauru i te wā roa ake, ka rerekē pea te whakawhitinga o te hītihāmina me ngā urupare i muri i te mātauranga. Ka whirihora ngā kaimātai i te mātauranga mā te whakamahi i ngā kōnehu iti ake me ngā wā hoki roa ake.

He āhua kino anō rānei e hono ana ki ngā taputapu PDT?

Āe, ko ngā āhua kino e noho ana ko te whero, te putake, me te māmā o te wera, āhuareka ana mō ngā momo kiri māmā. Ka taea te whakahaere pai hei whakaiti i ēnei āhua.

He aha ngā aronga mua-mātai e āwhina ai i te whakaiti i te whakapīpī?

Ko te ārotake i te māmā o te kiri me te whirihora i ngā tautuhinga o te taputapu PDT he mea matua herekore. Ka taea te whakaiti i te whakapīpī mā ngā kaiwhakangahau mā te mārama iti ake me ngā wā pāhua poto ake.

He aha ngā tikanga tiaki e tūtohua ana i muri i te mātai PDT?

Ko te tiaki muri i te mātai ko te whakakore i te noho tūmau i te rā, te whakamahi i ngā horoi māmā, me te whakaputa i ngā hinu pouaka kia tiakina te ara kiri.

He pai te PDT mō te whakahaere roa o te kiri māmā?

Āe, ko te PDT he whiringa kore pāpaku, he iti noa ngā mōrearea o te matepukutia, ā, ka taea e ia te hoatu painga roa mō ngā kiri māmā engari kāore he hiahia ki ngā rongoā tata.